As the vibrant aroma of sizzling meat filled my kitchen, I felt transported to a cozy Italian trattoria, where comfort food reigns supreme. This Uptown Meatloaf is my special twist on a classic, blending beef and pork with an enticing mix of herbs and spices, topped with gooey melted mozzarella and sun-dried tomatoes. It’s a heartwarming dish that not only pleases the family palate but also whips up in no time—perfect for those busy weeknights. Not to mention, this recipe is effortlessly adaptable, allowing you to substitute meats and flavors to fit your mood. So, are you ready to elevate your meatloaf game and make a dish that’s sure to impress?

Why is Meatloaf a Family Favorite?
Heartwarming comfort: This Uptown Meatloaf brings the joys of homemade cooking right to your table, creating a cozy atmosphere perfect for family gatherings. Adaptable and versatile: With options for different meats and flavors, you can easily customize this dish to suit every taste preference, whether opting for turkey or adding your favorite spices. Quick preparation: This recipe is simple and ideal for busy weeknights, so you can enjoy layers of rich flavor without extensive prep time. Melt-in-your-mouth goodness: The combination of mozzarella and sun-dried tomatoes creates a delightful, cheesy topping that enhances every bite. Pair it with a side of roasted vegetables or whip up some delicious meatloaf sandwiches for lunch the next day! Do you want to explore more comforting recipes? Check out my Low Carb Vegetarian for a tasty alternative!
Meatloaf Ingredients
For the Meatloaf
• Beef Sirloin – Provides a robust flavor and tender texture; substitute with ground turkey for a leaner version.
• Fatty Pork Shoulder – Adds moisture and richness; essential for texture; if avoiding pork, try using ground veal for a similar fat content.
• Fennel Seeds – Infuses a subtle anise flavor, enhancing the meat’s complexity; these can be omitted or replaced with Italian seasoning if preferred.
• Onion – Offers foundational sweetness and texture; a shallot can be used as a milder alternative.
• Garlic – Adds essential aromatics and flavor depth; fresh minced garlic is best, while garlic powder is a possible substitute.
• Fresh Bread Crumbs – Provides structure and binds the ingredients together; crushed crackers or panko are good alternatives.
• Italian Parsley – Brightens the dish with fresh flavor; can be substituted with fresh basil or omitted for a non-herb version.
• Sea Salt and Pepper – Essential for enhancing all flavors; adjust to taste based on dietary restrictions.
• Eggs – Bind the ingredients and provide moisture; any egg substitute can work in baking applications.
• V-8 Juice – Adds subtle acidity and moisture; can be replaced with tomato juice or a homemade vegetable puree.
• Dry White Wine – Contributes depth and enhances flavor; use vegetable broth or omit if desired.
For the Topping
• Sun-Dried Tomatoes – Adds sweetness and chewiness; fresh tomatoes can be used when in season for a different texture.
• Fresh Mozzarella – Offers a gooey, creamy topping that ties the dish together; this can be replaced with provolone or omitted entirely.
• Fresh Basil – For garnishing; can substitute with dried basil at a lesser quantity.
Embrace the magic of this meatloaf, drawing from flavors that promise to make dinner a cozy experience!
Step‑by‑Step Instructions for Uptown Meatloaf
Step 1: Preheat the Oven
Begin by preheating your oven to 400°F (200°C). This ensures that the Uptown Meatloaf will cook evenly and develop a beautiful brown crust. As the oven warms up, gather your ingredients and prepare your mixing bowls, so everything is ready for the next steps.
Step 2: Grind the Meats
Coarsely grind the beef sirloin and fatty pork shoulder together with the fennel seeds using a meat grinder or food processor. This process blends the flavors, creating a rich base for your meatloaf. Aim for a slightly chunky texture that will make your finished dish heartier—around 1-2 minutes of grinding should do the trick.
Step 3: Mix the Ingredients
In a large mixing bowl, combine the ground meats with eggs, fresh breadcrumbs, chopped parsley, diced onion, minced garlic, V-8 juice, white wine, sea salt, and black pepper. Gently mix until just combined, making sure not to over-mix, as this can result in a tough meatloaf. The mixture should be moist but hold together well.
Step 4: Prepare for Baking
Line a baking sheet with parchment paper for easy cleanup. Take the meat mixture and spread it out evenly onto the baking sheet, forming a rectangular shape about 1-inch thick. This will help the Uptown Meatloaf cook evenly and allows for a perfect roll later on.
Step 5: Add Toppings
Evenly sprinkle the top of the meat mixture with sun-dried tomatoes, fresh basil, and 3/4 of the mozzarella cheese. These delicious toppings will add sweetness and cheesy goodness to each bite, enhancing the flavor of the Uptown Meatloaf. You can gently press them into the mixture for a more cohesive profile.
Step 6: Roll the Meatloaf
Starting from one end of the rectangle, carefully roll the meat mixture jelly-roll style. Make sure to keep the toppings inside as you roll, creating a delightful spiral of flavors. Pinch the ends to seal the meatloaf so it holds its shape while baking.
Step 7: Bake the Meatloaf
Place the rolled meatloaf in the preheated oven and bake for about 1 hour. Halfway through cooking, remove the meatloaf and sprinkle on the remaining mozzarella cheese, then return it to the oven. After an hour, the cheese should be melted and golden, and the meatloaf will be browned on the outside.
Step 8: Let it Rest
Once baked, remove the Uptown Meatloaf from the oven and allow it to cool for 10 minutes before slicing. This resting period is essential for maintaining juiciness and making it easier to cut without falling apart.
Step 9: Serve and Enjoy
Slice the meatloaf with a sharp knife and serve it warm, either on its own or with a side of marinara sauce or tomato gravy. The vibrant flavors and delightful textures will surely impress your family, making this Uptown Meatloaf a memorable centerpiece for your dinner table.

Expert Tips for Uptown Meatloaf
Moisture Matters: Ensure your meatloaf doesn’t dry out by using fatty pork or adding extra wet ingredients like V-8 juice.
Avoid Overmixing: Mix the meat mixture until just combined. Overmixing can lead to a dense and tough meatloaf instead of a tender one.
Resting Period: Allow the meatloaf to rest for 10 minutes before slicing. This helps maintain juiciness and allows for cleaner cuts.
Cheese Melting: Add the remaining mozzarella halfway through baking to achieve that perfect gooey topping that complements the overall flavors of the meatloaf.
Ingredient Substitutions: Feel free to experiment with different meats or spices to customize your Uptown Meatloaf to your family’s taste preference.
Toppings Galore: Don’t hesitate to load up on toppings like sun-dried tomatoes and fresh basil. They elevate your meatloaf to a delightful new level!
Storage Tips for Meatloaf
Fridge: Store cooked meatloaf in an airtight container for up to 3 days to maintain its delicious flavors and moisture.
Freezer: For longer storage, wrap individual slices tightly in plastic wrap, then place them in a freezer bag. Meatloaf can be frozen for up to 3 months.
Reheating: To enjoy your meatloaf again, reheat in the oven at 350°F until warmed through, approximately 20-25 minutes, ensuring a delightful texture.
Make-Ahead: You can prepare the meatloaf in advance but avoid adding toppings until just before baking. Store the unbaked meatloaf in the fridge for up to 24 hours.
Make Ahead Options
This Uptown Meatloaf is perfect for busy home cooks looking to save time without sacrificing flavor! You can prepare the meat mixture up to 24 hours in advance by combining all the ingredients (ground meats, eggs, breadcrumbs, herbs, and seasonings) and store it tightly covered in the refrigerator. Just be sure to mix it gently to prevent toughness. The shaped meatloaf can also be assembled and refrigerated for up to 3 days before baking. When you’re ready to enjoy, simply preheat your oven to 400°F, bake for about 1 hour (adding toppings midway), and you’ll have a savory, hearty meal that feels fresh and delicious!
Meatloaf – Unleash Your Creativity!
This Uptown Meatloaf is a versatile canvas, inviting you to customize each flavor layer to create a dish that suits your taste and dietary needs.
- Lean Turkey: Substitute beef or pork with ground turkey for a lighter, healthier option. You’ll enjoy a similar juicy texture without the extra fat.
- Spicy Kick: Add a dash of red pepper flakes or a tablespoon of your favorite hot sauce to the meat mixture for a zesty twist that ignites your taste buds. It’s a delightful surprise your family might love!
- Vegan Delight: Swap all animal products with a mix of lentils and quinoa, binding with flaxseed instead of eggs. Nutritional yeast can replace cheese, giving you a cheesy flavor without any dairy!
- Herb Infusion: Experiment with fresh herbs by adding a handful of chopped rosemary or oregano to the meat mixture for aromatic depth. It will evoke a garden-like freshness with every bite.
- Texture Boost: Substitute fresh breadcrumbs with crushed taco-flavored chips or even oats for added crunch! This little twist can make your meatloaf even more delightful and entertaining.
- Gourmet Cheese: Swap mozzarella for aged cheddar or crumbled feta for a more robust flavor profile. The richness of these cheeses will turn your meatloaf into a gourmet dish!
- Culinary Adventure: Replace V-8 juice with barbecue sauce for a smoky flavor that brings a whole new dimension. Serve it with coleslaw, and you’ll have a full barbecue experience!
- Savory Fruit: Introduce finely diced apples or pears into the mixture for a touch of sweetness that contrasts beautifully with the savory meat. It adds a lovely texture and unexpected burst of flavor!
If you’re feeling adventurous, dive into other comforting recipes like my delicious Parmesan Chicken Meatloaf. Discover new favorites and make every meal a reason to gather and celebrate!
What to Serve with Uptown Meatloaf
The comforting goodness of this hearty meatloaf is best complemented by a spread of delicious sides that enhance every bite.
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Creamy Mashed Potatoes: Creamy and buttery, they offer a smooth contrast to the meatloaf’s texture, perfect for soaking up the flavors.
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Garlic Roasted Broccoli: The nutty crunch of roasted broccoli adds freshness and balances the rich flavors of the meatloaf beautifully. Keep it simple; a sprinkle of garlic and olive oil bring out its best.
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Honey Glazed Carrots: Sweet and tender, these carrots add a pop of color and a natural sweetness that complements the savory meatloaf brilliantly.
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Caesar Salad: Crisp romaine, crunchy croutons, and a zesty dressing create a refreshing side that cuts through the meatloaf’s richness.
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Marinara Sauce: A warm drizzle of this classic Italian sauce not only enhances the meatloaf’s flavor but also brings a delightful moisture to each bite. Ideal for a comforting, cozy meal.
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Chardonnay: A glass of this white wine elevates the dining experience, with its crisp notes enhancing the savory flavors without overpowering them.
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Garlic Bread: Crunchy on the outside and soft on the inside, it complements the meatloaf while ensuring no sauce gets left behind. Plus, who can resist garlic bread?
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Apple Crisp: For a sweet finish, serve up this warm dessert that contrasts the savory meatloaf with its tender apples and crumbly topping. Perfect for a heartwarming end to your meal!

Uptown Meatloaf Recipe FAQs
What type of meat should I use for the best flavor?
I recommend using a mix of beef sirloin and fatty pork shoulder for a moist and flavorful Uptown Meatloaf. If you prefer a leaner option, ground turkey or chicken can also work well, just be mindful that the texture may be slightly drier.
How long can I store leftovers, and what’s the best way?
Cooked meatloaf can be stored in an airtight container in the fridge for up to 3 days. To maintain moisture, make sure the container is well-sealed to prevent it from drying out.
Can I freeze meatloaf, and how should I do it?
Absolutely! To freeze, wrap individual slices tightly in plastic wrap and place them in a freezer bag. This will keep them fresh for up to 3 months. When you’re ready to enjoy them, reheat in the oven at 350°F for about 20-25 minutes, or until warmed through.
What should I do if my meatloaf is too dry?
If your meatloaf turns out dry, it could be due to overcooking or using lean meats without enough moisture. In the future, ensure to keep an eye on cooking time and consider adding more wet ingredients, like V-8 juice or incorporating extra eggs to boost moisture levels.
Is this recipe suitable for those with gluten sensitivities?
This Uptown Meatloaf includes bread crumbs, which can be a concern for those with gluten sensitivities. To make it gluten-free, you can substitute the breadcrumbs with gluten-free alternatives like almond flour or gluten-free oats.
What can I use instead of eggs in this meatloaf recipe?
If you’re looking for an egg substitute, I often recommend using 1/4 cup of unsweetened applesauce or mashed banana per egg. For a more neutral option, flaxseed meal works great—mix 1 tablespoon of flaxseed meal with 2.5 tablespoons of water, let it sit for a few minutes to thicken, and then add to your mixture.

Savory Meatloaf with a Cheesy Italian Twist
Ingredients
Equipment
Method
- Preheat your oven to 400°F (200°C). Gather your ingredients while the oven warms up.
- Coarsely grind the beef sirloin and pork shoulder with the fennel seeds.
- In a large bowl, mix the ground meats with eggs, breadcrumbs, parsley, onion, garlic, V-8 juice, wine, salt, and pepper until just combined.
- Line a baking sheet with parchment paper, spread the meat mixture evenly forming a rectangular shape.
- Sprinkle the mixture with sun-dried tomatoes, basil, and 3/4 of the mozzarella.
- Roll the meatloaf jelly-roll style, sealing the ends.
- Place the rolled meatloaf in the oven and bake for about 1 hour.
- Halfway through baking, sprinkle the remaining mozzarella on top and return to the oven.
- Allow the meatloaf to rest for 10 minutes before slicing.
- Slice, serve warm, and enjoy!

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